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BSO can result in an 80% to 96% reduction in the risk of a BRCA-associated gynecologic cancer. In addition, it can reduce the risk of breast cancer by almost 50%. Nine (90%) centers stated that healthcare professionals (mainly gynecologists, genetic counselors and medical geneticists) offer advice to Lynch syndrome carriers about risk-reducing BSO. In 9/10 centers, risk-reducing BSO is advocated by healthcare professionals, and in 5/9 (56%), it is actively recommended. Of the 21 centers, 6 provided information about the involvement of patients in discussions about risk-reducing BSO. Three of those centers (50%) stated that surgery is only provided 2010-09-26 · Prophylactic BSO in a woman with an abnormal BRCA1 or BRCA2 gene can: reduce her risk of BRCA -related ovarian cancer by 96% reduce her risk of breast cancer by 50% to 80% (for premenopausal women) significantly reduce her risk of breast cancer coming back if she's been diagnosed If RRSO is performed before the age of 40 years, the risk reduction for breast cancer is 56% in BRCA1 mutation carriers (OR, 0.44; 95% CI, 0.29‐0.66) and 46% in BRCA2 carriers (OR, 0.57; 95% CI, 0.28‐1.15), with the effect persisting at least 15 years after the procedure.
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26 Sep 2010 To reduce future risk of ovarian and breast cancer, SGO guidelines or BRCA2 gene should have prophylactic BSO to reduce their risk after Bilateral salpingo-oophorectomy (BSO) What is a bilateral salpingo- oophorectomy, or BSO? counseled about the risks and benefits of hormone replacement therapy prior to undergoing surgery. 2.
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Although the etiology of this protection is incompletely understood, it is clear that in women who carry BRCA mutations, BSO confers significant pro Risk-reducing salpingo-oophorectomy (RRSO) • Removal of both ovaries and fallopian tubes • Most effective method of preventing ovarian cancer – 80% risk reduction of ovarian cancer • 0%–50% risk reduction of breast cancer Ideal timing: After completed child births, at 35–45 years Risk-reducing bilateral salpingo-oophorectomy (BSO) is the removal of healthy ovaries and fallopian tubes. Risk-reducing BSO surgery is highly recommended after completion of childbearing because screening methods have not been proven effective at detecting ovarian cancer. Key Words: Risk-reducing salpingo-oophorectomy, BRCA mutation carriers Received December 18, 2010, and in revised form February 9, 2011.
1 Nov 2019 We intend to review the “best practices” recommended by ACOG when performing a risk-reducing bilateral salpingo-oophorectomy (RR-BSO)
16 Jul 2014 Key content The lifetime risk of ovarian cancer in the general population is 1.4% but women with hereditary ovarian cancer syndromes have a
In breast cancer susceptibility gene (BRCA) carriers, prophylactic risk-reducing BSO significantly reduces ovarian cancer risk.
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Rocca et al. found that premenopausal uni- or bilateral oophorectomy increased the risk of dementia and … 2021-01-30 2010-09-27 Risk‐reducing surgery could potentially form one of the many options in the breast cancer treatment armamentarium already complex to a degree that it requires decision‐making algorithms. Risk-reducing salpingo-oophorectomy (RRSO) • Removal of both ovaries and fallopian tubes • Most effective method of preventing ovarian cancer – 80% risk reduction of ovarian cancer • 0%–50% risk reduction of breast cancer Ideal timing: After completed child births, at 35–45 years Risk reducing surgery with removal of ovaries and tubes for genetic predisposit Dr Herbert Gretz illustrates techniques for laparoscopic gynecologic surgery. The objective of the UPTAKE study was to explore rates and predictors of risk-reducing BSO among Latinas affected and unaffected with breast cancer who had a deleterious BRCA1/2 mutation. We recruited 100 Latina women with deleterious BRCA1/2 mutations from community hospitals, academic health systems, community, and advocacy organizations. Pro- BSO may also be performed to reduce the actual or perceived increased risk of ovarian cancer (risk-reducing RR-BSO). This is because: Ovarian cancer typically present at an advanced stage, where the survival rate is less than 20%.